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Deshpande, A. D.
- Evaluation of Antihyperlipidemic Activity of Mimusops elengi L. in Triton WR- 1339 Induced Hyperlipidaemia in Rats
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PDF Views:731
Authors
Source
Journal of Natural Remedies, Vol 8, No 2 (2008), Pagination: 132-137Abstract
Objective: The present study was undertaken to explore antihyperlipidemic effect of ethanolic extract of Mimusops elengi L. (ME) in Triton WR-1339 induced hyperlipidemia in rats. Materials and methods: The wistar rats were divided in to Normal control (NC), Hyperlipidemic group (HG), Fenofibrate group (FG), Mimusops elengi L. (ME) treated groups (100, 300, 600 mg/kg, p.o.). Hyperlipidemia in all groups was induced by single i.p. injection of Triton WR-1339 at a dose of 200 mg/kg except normal control. Result: The groups treated with Mimusops elengi L. showed significant reduction (p<0.01) in levels of triglyceride and total cholesterol as compared to HG after 7 and 24 h of induction. Even after 48 h the groups treated with Mimusops elengi L. showed significant decrease (p<0.01) in level of triglyceride in groups ME 300, ME 600 and significant decrease (p<0.05) in level of total cholesterol in groups ME 300, ME 600 respectively as compared to HG. Moreover HDL level was significantly elevated (p<0.01) in the groups ME 300, ME 600 after 7 and 24 h, however it was significantly elevated (p<0.01) only in ME 600 after 48 h of the treatment. Conclusion: Hence it can be concluded that Mimusops elengi L. has significant antihyperlipidemic effect owing to its ability to reduce the levels of total cholesterol, triglyceride and increasing the level of HDL.Keywords
Hyperlipidemia, Mimusops elengi L., Triton WR- 1339- Simultaneous Spectrophotometric Estimation of Enalapril Maleate and Losartan Potassium in Tablet Dosage form and It's Application to Dissolution Study
Abstract Views :187 |
PDF Views:80
Authors
A. B. Thomas
1,
A. A. Chaudhari
1,
R. K. Nanda
1,
L. P. Kothapalli
1,
U. B. Chavan
1,
A. D. Deshpande
1
Affiliations
1 Department of Pharmaceutical chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune - 411 018, Maharashtra, IN
1 Department of Pharmaceutical chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune - 411 018, Maharashtra, IN
Source
Journal of Pharmaceutical Research, Vol 8, No 2 (2009), Pagination: 85-88Abstract
Two spectrophotometric methods have been developed for the simultaneous estimation of Enalapril Maleate (Ena) and Losarton Potassium (Los) in combined tablet dosage forms. The first method involves determination using the absorbance correction method, the sampling wavelengths selected are, 222 nm and 250 nm over the concentration ranges of 2-32 mcg/mL and 1-60 mcg/mL for Ena and Los respectively. The second method is the second order derivative method, the sampling wavelength selected for estimation of Ena and Los are 219.5 nm and 264 nm which show linearity in the concentration ranges of 2-32 mcg/mL and 1-60 mcg/mL respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines. Also the developed methods were successfully employed for dissolution studies in tablet dosage form.Keywords
Enalapril, Losartan, Absorbance Correction Method, Second Order Derivative Method, Dissolution Studies.- Simultaneous Spectrophotometric Estimation of Hydrochlorothiazide, Atenolol and Losartan Potassium in Tablet Dosage Form
Abstract Views :154 |
PDF Views:74
Authors
Affiliations
1 Department of Pharmaceutical chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, Maharashtra, IN
1 Department of Pharmaceutical chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, Maharashtra, IN
Source
Journal of Pharmaceutical Research, Vol 8, No 3 (2009), Pagination: 139-141Abstract
Two UV spectrophotometric methods have been developed for the simultaneous estimation of Hydrochlorothiazide (Hctz), Atenolol (Atn) and Losartan Potassium (Los) in combined tablet dosage forms. The first method involves determination using the Area under curve, the sampling wavelength intervals selected are 274.5-270.5 nm, 226-222 nm and 252-248 nm over the concentration ranges of 0.5-30 mcg mL-1, 1-50 mcg mL-1 and 1-60 mcg mL-1 for Hctz, Atn and Los respectively. The second method involves determination using the multicomponent mode of the UV visible spectrophotometer, the sampling wavelengths selected are 272.5 , 224 and 250 nm over the concentration ranges of 0.5-30 mcg mL-1, 1-50 mcg mL-1 and 1-60 mcg mL-1 for Hctz, Atn and Los respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines. The developed methods are simple, rapid, precise, accurate and can be employed for the routine estimation of Hydrochlorothiazide, Atenolol and Losartan Potassium in both bulk and tablet dosage form.Keywords
Hydrochlorothiazide, Atenolol, Losartan Potassium, Area under Curve Method, Multicomponent Mode Method.- Simultaneous Spectrophotometric Methods for Estimation of Cefpodoxime Proxetil and Potassium Clavulanate in Tablet Dosage form
Abstract Views :189 |
PDF Views:80
Authors
A. B. Thomas
1,
S. B. Dighe
1,
L. P. Kothapalli
1,
R. K. Nanda
1,
S. N. Jagdale
1,
A. D. Deshpande
1
Affiliations
1 Department of Pharmaceutical Chemistry, Pad. Dr. D.Y.Patil Institute Of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, Maharashtra, IN
1 Department of Pharmaceutical Chemistry, Pad. Dr. D.Y.Patil Institute Of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, Maharashtra, IN
Source
Journal of Pharmaceutical Research, Vol 9, No 4 (2010), Pagination: 167-171Abstract
Three UV spectrophotometric methods have been developed for the simultaneous estimation of Cefpodoxime proxetil (Cef) and Potassium clavulanate (Pot.clav.) in combined tablet dosage forms. The first method involves Q-absorbance ratio method, the sampling wavelengths selected are, 315.0nm (isoabsorptive point) and 233.0 nm (lmax of Cef). The second method is the First order derivative method, the sampling wavelengths selected are 269.0 nm and 240.0 nm for estimation of Cef and Pot.clav. respectively. In both the methods, the linearity range for both Cef and Pot.clav. was in the concentration range of 1.5-50 μg mL-1. The third method based on ratio derivative spectrophotometry, involves measurement of absorbances at the amplitudes in the first order derivative of the ratio spectra at 246.0 nm and 327.0 nm for Cef and Pot.clav. respectively over the concentration range of 2.5-50 μg mL-1for both the drugs. The results of the analysis were validated statistically and recovery studies carried out as per ICH guidelines. The developed methods are rapid, precise, accurate, rugged and can be employed for the routine estimation of Cefpodoxime proxetil and Potassium clavulanate in both bulk and tablet dosage form.Keywords
Cefpodoxime Proxetil, Potassium Clavulanate, Q-Absorbance Ratio Method, First Order Derivative Spectroscopy, Ratio Spectra Derivative Spectrophotometry.- Stability Indicating Hptlc Method for the Simultaneous Determination of Amlodipine Besylate and Telmisartan from Tablet Dosage Form
Abstract Views :212 |
PDF Views:84
Authors
Affiliations
1 Pad.Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research Pimpri, Pune-18, Maharashtra, IN
1 Pad.Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research Pimpri, Pune-18, Maharashtra, IN
Source
Journal of Pharmaceutical Research, Vol 10, No 2 (2011), Pagination: 66-72Abstract
Amlodipine besylate and Telmisartan are used in the treatment of hypertension. A simple, selective and stability indicating High-performance thin-layer chromatography method has been established for the simultaneous analysis of Amlodipine besylate and Telmisartan. The method uses aluminum-backed silica gel 60F254 TLC plates as stationary phase with ethyl acetate: methanol: ammonia: glacial acetic acid [7.5:1.5:1.0:0.2 (v/v/v/v)] as mobile phase. Densitometric analysis was carried out in the absorbance mode at 226 nm. This system was found to give compact bands for Amlodipine besylate and Telmisartan with Rf values of 0.34±0.02 and 0.60±0.02 respectively. Linear relationships were obtained between response and amount of drug with high correlation coefficients (r2) in the range 500-6000 ng band-1 for Amlodipine besylate (r2=0.9951) and 1000-8000 ng band-1 for Telmisartan (r2= 0.9982). The method was validated for precision, accuracy and robustness as per ICH guidelines. Amlodipine besylate and Telmisartan were subjected to acid, base, oxidation, dry heat, wet heat and photo degradation studies. The degradation products obtained were well resolved from the pure drugs with significantly different Rf values. As the method could effectively separate the drugs from its degradation products, it can be used for stabilityindicating analysis.Keywords
Amlodipilne Besylate, Telmisartan, HPTLC.- Estimation of Nateglinide and Metformin Hydrochloride in Tablet Dosage form by Spectrophotometric Methods
Abstract Views :156 |
PDF Views:86
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Padm. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, IN
1 Department of Pharmaceutical Chemistry, Padm. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, IN